Description

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a naturally occurring mitochondrial-derived peptide (MDP) that has emerged as a significant focus of research in metabolic health, cellular signaling, and longevity science. Unlike most signaling molecules, which are encoded by nuclear DNA, MOTS-c is encoded within the mitochondrial genome and functions as an important messenger between mitochondria and the cell nucleus.

Researchers have identified MOTS-c as a key regulator of metabolic homeostasis, with studies suggesting it may influence cellular energy utilization and adaptive metabolic responses. A major area of investigation involves its interaction with the AMP-activated protein kinase (AMPK) pathway, a critical regulator of energy balance, nutrient sensing, and cellular metabolism.

Research indicates that MOTS-c may promote metabolic flexibility by enhancing glucose utilization and supporting fatty acid oxidation. Due to these effects, it is often studied as an “exercise mimetic,” with investigations exploring its potential to improve skeletal muscle metabolism, endurance, and overall energy efficiency.

MOTS-c has also attracted considerable interest in studies related to insulin sensitivity and metabolic health. Preclinical research suggests it may help support healthy glucose metabolism and maintain metabolic balance under conditions of physiological stress. Additionally, emerging evidence points to a potential role in healthy aging, cellular resilience, and the maintenance of protein homeostasis, making it a promising subject in longevity-focused research.

Product Highlights

• Compound: MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c)
• Type: Mitochondrial-Derived Peptide (MDP)
• Sequence Length: 16 Amino Acids
• Form: Lyophilized, TFA-Removed Peptide
• Research Focus: Metabolic regulation, mitochondrial function, exercise physiology, and longevity studies

Research Applications

• Metabolic flexibility and energy utilization
• AMPK pathway activation research
• Glucose metabolism and insulin sensitivity studies
• Mitochondrial communication and function
• Exercise performance and endurance investigations
• Healthy aging and longevity research
• Cellular resilience and proteostasis studies

Purity & Research Integrity

Our MOTS-c is synthesized using advanced solid-phase peptide synthesis techniques to ensure exceptional purity, consistency, and sequence accuracy. Each batch undergoes rigorous quality testing to verify identity and concentration. The peptide is supplied in a lyophilized, TFA-removed format to maximize stability, solubility, and reliability for both in vitro and in vivo research applications.

Package Includes

• (1) Vial of Lyophilized Peptide Powder

Important Notes

• Bacteriostatic water is required for reconstitution and is not included.
• Syringes and additional laboratory supplies are not included.
• All peptides are intended exclusively for research applications.

For laboratory research use only. Not intended for human or animal consumption, medical use, diagnosis, treatment, or prevention of any disease.